Oliveira YP, Pontes-de-Carvalho LC, Couto RD, Noronha-Dutra AA
OSR efficiently and safely restores chondrocyte activity in DMM model mice To evaluate OSRs chondroprotective and antiosteoarthritic effects in vivo, a DMM model was established in C57BL/6 mice with five groups: Sham, DMM, DMSO, OSR 25 mg/kg, and OSR 50 mg/kg (Fig
However, in contrast to the maternal reproductive tract, insufficient antioxidant levels in the in vitro culture environment, weakening of the cellular antioxidant mechanism, or excessive cellular oxygen production for various reasons, resulting in increased ROS accumulation, are the cause of oxidative stress 19,20,24
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The prescription of GZFLD consists of five herbs: poria cocos, persicae semen, paeoniae radix, cinnamon cortex, and moutan cortex ( Table S3 )